Extended Data Fig. 7: Impact of CDDP on CXCL10 production by intratumor immune cells.
From: Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses
Violin plot showing expression level of a, Lta and b, Ltb genes in cells belonging to the ILC3 CCR6 cluster at each time point, measured by sc RNA-seq from TC-1 tumors, as described in Fig. 1. c–m, Flow cytometry analysis of CXCL10 expressing cells from TC-1 tumors treated with PBS or CDDP, one, three and seven days before. Percentages of CXCL10+ in c, ILC1s, d, ILC2s, e, NKs, f, CD4+ cells, g, CD8+ cells, h, DCs, i, B cells, j, macrophages, k, M-MDSCs, l, PMN-MDSCs, m, eosinophils, n = 6. n, numbers of eosinophils from tumors treated as in c-m n = 6. Numbers are shown for 300 000 total viable cells from each TC-1 tumor. o, representative flow cytometry plot of CXCL10 expression. Results are shown as mean ± SD and are representative of three independent experiments. Statistical significance was determined using two-way anova and Tukey’s multiple comparison test (c–n).
