Extended Data Fig. 5: Correlation between hmC, H3K4Me3, and H3K36Me3. | Nature Immunology

Extended Data Fig. 5: Correlation between hmC, H3K4Me3, and H3K36Me3.

From: Whole-genome profiling of DNA methylation and hydroxymethylation identifies distinct regulatory programs among innate lymphocytes

Extended Data Fig. 5

Correlation between hmC, H3K4Me3, and H3K36Me3. a, Enrichment profiles for DNA methylation, H3K4Me3, and H3K36Me3 in NK cells. b, Comparison of 5mC and 5hmC at 5kb windows centered on super-enhancers and control enhancers (n=877). Boxes extend from the 25th to 75th percentiles, whiskers extend to 1.5 times the IQR, and the center line is the median. Statistical significance calculated using unpaired two-tailed Student’s t-test. c, Scatterplots comparing RNA, H3K27Ac, or p300 signal with 5hmC abundance at NK super-enhancers. Statistical significance calculated with the Pearson correlation coefficient. Trendline indicates linear regression fitting with shaded areas corresponding to 95% confidence intervals.

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