Extended Data Fig. 6: TET2 supports ILC effector functions in a cell-intrinsic manner. | Nature Immunology

Extended Data Fig. 6: TET2 supports ILC effector functions in a cell-intrinsic manner.

From: Whole-genome profiling of DNA methylation and hydroxymethylation identifies distinct regulatory programs among innate lymphocytes

Extended Data Fig. 6

TET2 supports ILC effector functions in a cell-intrinsic manner. a, Diagram of mixed BM chimera generation. b, Donor-derived chimerism of NK, ILC2, and ILC3 (n=3). c-e, IFNγ production by splenic NK cells in response to c, IL-12 (10ng/mL) and IL-18 (1ng/mL) d, NK1.1 cross-linking and e, Yac-1 target cells. f, Granzyme-B production by splenic NK cells in response to Yac-1 cells. g, IL-5 and h, IL-13 production by ILC2 following stimulation with PMA/Ionomycin. i, Production of IL-17A by ILC3 following stimulation with IL-23 (10ng/mL) (c-i; n=6). Statistical significance calculated using paired two-tailed Student’s t-test. Each symbol represents an individual mouse. Data are representative of three independent experiments (b) or pooled from two independent experiments (c-i).

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