Extended Data Fig. 7: TET2 is not required for NK cell responses to MCMV.

TET2 is not required for NK cell responses to MCMV. a, Diagram of single BM chimera generation. b, Splenic NK maturation on day 4 post-infection (n=3). c, Frequency of Ly49H⁺ NK cells on day 4 post-infection (n=3). Production of d, IFNγ (n=3), e, TNFα (n=5), and f, Granzyme-B (n=3) by splenic NK cells after 4 hours of incubation with brefeldin A. Frequency of g, KLRG1⁺ and h, CD69⁺ NK cells (g-h;n=3). Frequency of i, Ly49D⁺ Ly49A⁻, j, Ly49A⁺ Ly49D⁺, and k, Ly49A⁺ Ly49D⁻ NK cells (i-k;n=5). Statistical significance calculated using unpaired two-tailed Student’s t-test. Each symbol represents an individual mouse; small horizontal lines indicate the mean (± s.e.). Data are representative of two independent experiments (b-d, f, g-h) or pooled from two independent experiments (e, i-k).