Fig. 4: Induction of S751-specific CD4+ T cells following primary vaccination.
From: Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory
a, Frequencies of S751-specific T cells at baseline, week 3 after dose 1 or week 2 after dose 2 among nine previously uninfected individuals. Statistics were assessed by the Wilcoxon test. b, Representative staining of the S751 tetramer among CD4+ T cells following immunization with one dose of BNT162b2 in a previously uninfected individual. c, Longitudinal S751-specific T cell frequencies at baseline and following BNT162b2 vaccination among nine previously uninfected individuals. Closed circles indicate samples collected after dose 1, and open circles indicate samples collected after dose 2. d, CCR6 and CXCR3 expression on TET751+ cells at week 3 after dose 1 or week 2 after dose 2 among seven individuals vaccinated with BNT162b2. Lines indicate the median, and bars indicate the IQR. e, Longitudinal S751-specific cTFH cell frequencies at baseline and following BNT162b2 vaccination among seven previously uninfected individuals. Closed circles indicate samples collected after dose 1, and open circles indicate samples collected after dose 2. f, Circos plots indicating pairing of TRAV and TRBV genes among sorted TET751+ cells for three individuals after the second vaccine dose.
