Extended Data Fig. 7

(a, b) Analysis of TCR-induced signaling events in Lag3^–/–CD8⁺ T cells, isolated as above, transduced with LAG3^WT or LAG3 functional domain mutants and stimulated with TCRβ Abs. Representative super-resolution confocal images are depicted, with quantification of single cell intensity measurements collected from two independent experiments presented as percent of LAG3-deficient parental cells as control (Scale bar 2 µm). Statistics determined by unpaired Student’s two sided t test. P values are noted in figures.