Extended Data Fig. 4: Significant upstream regulators (p value of overlap < 0.05; -2 ≤ z-score ≥ 2) at 1.5 hr post injection of mIL-2/CD25. | Nature Immunology

Extended Data Fig. 4: Significant upstream regulators (p value of overlap < 0.05; -2 ≤ z-score ≥ 2) at 1.5 hr post injection of mIL-2/CD25.

From: Dynamic transcriptional activity and chromatin remodeling of regulatory T cells after varied duration of interleukin-2 receptor signaling

Extended Data Fig. 4

The horizontal bars denote the different regulators based on the activation z-score. Red color indicates activation, while blue color indicates inhibition. (b) Top gene network related to ‘Cellular Development, Cellular Growth and Proliferation, Lymphoid Tissue Structure and Development’ in Tregs 1.5 hrs post injection. TCR and STAT5 were identified as key hubs.

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