Extended Data Fig. 2: Biological features of CD34+CD45RA+CD64dimCD115− cells, cMoPs and MDPs prior to, and after treatment with, either SFGc, or SFG.
From: CD66b−CD64dimCD115− cells in the human bone marrow represent neutrophil-committed progenitors
a, Bar graphs depicting the percentage of PI−, live cells generated by CD34+CD45RA+CD64dimCD115−cells (n = 8), cMoPs (n = 7) and MDPs (n = 4) treated with SFGc for 7 days. Data represent means ± s.e.m. b, Bar graphs showing the fold expansion of CD34+CD45RA+CD64dimCD115−cells (n = 8), cMoPs (n = 6) and MDPs (n = 4) treated with SFGc for 7 days. Data represent means ± s.e.m. Analysis was performed by using Kruskal-Wallis test, Dunn’s post-hoc test. c, Representative histogram overlays showing the expression of CD114 by CD34+CD45RA+CD64dimCD115−cells (green), cMoPs (light blue) and MDP (brown) populations. Gray profile corresponds to isotype control (n = 3). (d) Bar graphs reporting the percentages of neutrophils (green), cDC1s (magenta), pDCs/preDCs/DC5s (orange), monocytes (light blue) and cDC2s (pink) generated by CD34+CD45RA+CD64dimCD115− cells (n = 8), cMoPs (n = 9) and MDPs (n = 6) treated with SFG for 7 days. Data represent means ± s.e.m.
