Fig. 3: Humoral response 14–45 days after the second and third vaccine doses.
From: Superior immunogenicity and effectiveness of the third compared to the second BNT162b2 vaccine dose
a–c, Scatter plot analysis of IgG antibodies (n = 3,478 after the second dose and n = 1,098 after the third dose) (a) and neutralizing titers (n = 665 after the second dose and n = 693 after the third dose) (b) and avidity scatter plot and before/after analysis (n = 81) (c) in HCWs after the second (Post 2nd) and third (Post 3rd) vaccine doses. The dotted black line indicates the cutoff level of positive antibodies and neutralizing concentrations. The black bars indicate GMT ± 95% CI. All numbers (n) reflect biologically independent samples. GMT of each time point is indicated. d–g, IgG (d,f) and neutralizing antibodies (e,g) after the second and third doses according to age group (n = 2,697 and n = 780 after the second dose and n = 1,028 and n = 204 after the third dose in HCWs <60 years and ≥60 years, respectively, for IgG (d) and n = 383 and n = 281 after the second dose and n = 444 and n = 248 after third dose in HCWs <60 years and ≥60 years, respectively, for neutralizing antibodies (e)) and sex (n = 932 and n = 2,545 after the second dose and n = 276 and n = 956 after the third dose in male and female HCWs, respectively, for IgG (f) and n = 154 and n = 510 after the second dose and n = 186 and n = 506 after the third dose in male and female HCWs, respectively, for neutralizing antibodies (g)). Expected GMT is indicated for each group. Dots represent individual observed serum samples. The black bars indicate GMT ± 95%CI.. All numbers (n) reflect biologically independent samples.
