Extended Data Fig. 1: Cluster-defining marker plots for all clusters and heatmap of differential gene expression analysis among the three CD8+ T cell clusters. | Nature Immunology

Extended Data Fig. 1: Cluster-defining marker plots for all clusters and heatmap of differential gene expression analysis among the three CD8+ T cell clusters.

From: Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies

Extended Data Fig. 1: Cluster-defining marker plots for all clusters and heatmap of differential gene expression analysis among the three CD8+ T cell clusters.

a, Marker plots showing normalized expression of selected common markers for lymphoid and myeloid populations (CD3D – T cells, CD4 – CD4+ T cells, CD8A – CD8+ T cells, KLRB1 – innate lymphocytes, CD14 – myeloid cells). b, Heatmap of expression of the top 30 DEGs by log fold change, [computed using Wilcox test in the FindMarkers() function of Seurat (FDR P < 0.05 and LFC > 0)], across the three CD8+ T cell clusters within the chRCC and ccRCC patients. Each column represents an individual cell. c, Plots showing the back gating strategy for plots shown in Fig. 1e.

Back to article page