Extended Data Fig. 2: Heatmap of differential gene expression analysis between clusters NK and ILC1 and comparison of CD56 expression between CD49a+CD103+ ILC1s and CD49a−CD103− NK cells. | Nature Immunology

Extended Data Fig. 2: Heatmap of differential gene expression analysis between clusters NK and ILC1 and comparison of CD56 expression between CD49a+CD103+ ILC1s and CD49a−CD103− NK cells.

From: Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies

Extended Data Fig. 2

a, Heatmap of expression of the top 30 DEGs by log fold change, [computed using Wilcox test in the FindMarkers() function of Seurat (FDR P < 0.05 and LFC > 0)], across the two innate lymphocyte clusters in the chromophobe renal cell carcinoma (chRCC) and clear cell RCC (ccRCC) patients. Each column represents an individual cell. b, Plots showing the back gating strategy for plots shown in Fig. 2c. c, CD56 MFI in CD49a+CD103+ ILC1s (orange) compared to CD49a−CD103− NK cells (green) in the indicated histology. Each pair of symbols connected by a line denotes an individual patient (chRCC n = 9, ccRCC n = 15). Paired ratio t test was used for statistical analysis, NS = non-significant, ****p < 0.0001.

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