Fig. 2: Hypoxic acute lung injury replicates early monocytopenia in mice and alters the circulating monocyte phenotype.
From: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
a, Blood leukocyte counts, monocyte counts and proportion of blood monocyte subgroups in naive or LPS-treated mice housed in normoxia or hypoxia for 24 h. b, Classical monocyte (CD115+CD11b+Ly6Chi) surface expression of ICAM, CD11a and CCR2 at 24 h post-LPS. c, Blood leukocyte counts, monocyte counts and proportions of monocyte sub-populations in naive or LPS-treated mice housed in normoxia or hypoxia for 5 d post-LPS. d, Differentially expressed genes in circulating classical monocytes from LPS-treated mice housed in normoxia or hypoxia for 5 d. Data represent the mean ± s.e.m. Data for a and c are pooled from two independent experiments. b is representative of 2 experiments (n=3-4/ group). Each datapoint represents an individual mouse. Statistical testing: one-way ANOVA with Tukey’s multiple comparison test (a and b).
