Extended Data Fig. 3: Immunoglobulin heavy and light chain germline gene enrichments in isolated mAbs compared to a reference human germline database. | Nature Immunology

Extended Data Fig. 3: Immunoglobulin heavy and light chain germline gene enrichments in isolated mAbs compared to a reference human germline database.

From: Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses

Extended Data Fig. 3: Immunoglobulin heavy and light chain germline gene enrichments in isolated mAbs compared to a reference human germline database.

Baseline germline frequencies of heavy chain genes (IGHV (a), IGHD (b) and IGHJ (c) genes) and light chain genes (IGKV and IGLV (d), IGKJ and IGLJ (e) genes) are shown in grey, and mAb, bnAbs and cross-reactive mAbs in a-e panels are colored according to the key in (a and d). Arrows indicate gene enrichments compared to human baseline germline frequencies. The gene usage enrichments in panels a-e are shown for all unique clone mAbs isolated from CC25 and CC84 donors. Data are shown as bar plots.

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