Extended Data Fig. 1: The MBL2 locus: structure and main association signals with severe COVID-19. | Nature Immunology

Extended Data Fig. 1: The MBL2 locus: structure and main association signals with severe COVID-19.

From: Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

Extended Data Fig. 1

A screenshot from the UCSC Genome browser (http://genome.ucsc.edu/; release Dec. 2013, GRCh38/hg38) specifically highlighting the 1-Mb region surrounding the MBL2 gene is shown. The panel reports, in order, the following tracks: i) the ruler with the scale at the genomic level; ii) chromosome 10 nucleotide numbering; iii) the UCSC RefSeq track; iv) COVID-19 risk variants from the COVID-19 HGI GWAS Analysis A2 (8,779 cases, 25 studies, Release 6: June 2021); v) COVID-19 risk variants from the COVID-19 HGI GWAS Analysis B2 (24,274 cases, 43 studies, Release 6: June 2021); vi) COVID-19 risk variants from the COVID-19 HGI GWAS Analysis C2 (112,612 cases, 74 studies, Release 6: June 2021); vii) COVID-19 risk haplotypes, marked by the tagging SNP, from our larger study (lollipops show all haplotypes reported in Table 2). All panels reporting COVID-19 risk variants from the COVID-19 HGI GWAS analysis show only signals at P < 5 × 10−3; the lollipop height and color depends on the -log10(P): dark pink indicates P < 10-4, orange indicates 10−4 < P < 10−3, light pink indicates 10−3 < P < 5 × 10−3.

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