Extended Data Fig. 7: TRM in distinct tissue microenvironments possess unique epigenetic programs. | Nature Immunology

Extended Data Fig. 7: TRM in distinct tissue microenvironments possess unique epigenetic programs.

From: Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

Extended Data Fig. 7

a-d, ATAC-seq of P14 CD8+ T cells in the spleen and IV− P14 CD8+ T cells isolated from the IEL, kidney, SG, fat, and liver. a, Pearson correlation for all peaks across all samples. b, Annotation of the genomic region type for all identified accessible regions (left) and DAR (right). c,d, Shared and unique upregulated DAR (c) and downregulated DAR (d) in each tissue compared to the spleen for all DAR with a p-value <0.05 and a fold change >4 using a Wald statistics.

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