Extended Data Fig. 6 | Nature Immunology

Extended Data Fig. 6

From: Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans

Extended Data Fig. 6

a, Representative FACS gating strategy of Roryt+ CD4+ TCR-β+ TH17 cells in pLNs two weeks after C. albicans colonization of Rorc-Cre Airefl/fl (WT) and Rorc-Cre+Airefl/fl (ILC3ΔAire) mice. b, Statistical analysis of related to a). The plot is showing the frequency from parent gate (n = 6, mean ± SD, two-tailed Student’s t-test). c, Representative FACS gating strategy of Roryt+ CD4+ TCR-β+ TH17 cells in mesenteric lymph nodes (mLN) two weeks after C. albicans colonization of Rorc-Cre Airefl/fl (WT) and Rorc-Cre+Airefl/fl (ILC3ΔAire) mice. d, Statistical analysis of related to c). The plot is showing the frequency from parent gate (n = 6, mean ± SD, two-tailed Student’s t-test). e, Representative FACS gating strategy of Roryt+ CD4+ TCR-β+ TH17 cells in lamina propria two weeks after C. albicans colonization of Rorc-Cre Airefl/fl (WT) and Rorc-Cre+Airefl/fl (ILC3ΔAire) mice. f), Statistical analysis of related to e). The plot is showing the frequency from parent gate (n = 6, mean ± SD, two-tailed Student’s t-test). P-value indicators: ** =P-value < 0.001, * = P-value < 0.05, ns = not significant.

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