Extended Data Fig. 8: Regulation of m6A modified mRNAs by Wtap deletion. | Nature Immunology

Extended Data Fig. 8: Regulation of m6A modified mRNAs by Wtap deletion.

From: The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells

Extended Data Fig. 8: Regulation of m6A modified mRNAs by Wtap deletion.

a, qPCR analysis of iKO and control CD4+ T cells. Results are presented relative to Ywhaz expression. (WT, n = 4; KO, n = 3, two independent experiments with technical triplicates). (mean ± s.e.m, unpaired two-tailed t-test). b, mRNA decay curves of Tnfrsf1b mRNA in iKO and control CD4+ T cells using Actinomycin D to terminate transcription of newly synthesized mRNAs. (n = 3, two to three independent experiments with technical triplicates). (mean ± s.e.m, two-way ANOVA).

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