Extended Data Fig. 5: Runx3 promotes epigenetic remodeling in CD4+ T cells. | Nature Immunology

Extended Data Fig. 5: Runx3 promotes epigenetic remodeling in CD4+ T cells.

From: Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells

Extended Data Fig. 5: Runx3 promotes epigenetic remodeling in CD4+ T cells.

(a) Scatter plots showing peak accessibility changes in CD8-Ctrl cells treated with TGF-β vs Ctrl and CD4-Ctrl (top) or CD4-Runx3 (bottom) treated with TGF-β vs Ctrl. (b) Scatter plots showing peak accessibility changes in CD8-Runx3 vs CD8-Ctrl cells and CD4-Runx3 vs CD4-Ctrl treated with TGF-β (bottom) or untreated (top; orange dots highlight TGF-β regulated genes). (c) Itga1, Cd244, S1pr1 and Ly6c genome tracks (height normalized) in CD4+ gDT-II and CD8+ gBT-I cells transduced with control (CD4-Ctrl and CD8-Ctrl) or Runx3-expressing (CD4-Runx3 and CD8-Runx3) retroviruses cultured ± TGF-β for 48 hours. Data representative of 2 independent experiments, with n=2 technical replicates.

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