Fig. 3: SARS-CoV-2-specific T cells are enriched in the lungs.

a,b, Frequency of TNF- (a) or IFN-γ-producing (b) CD4⁺ and CD8⁺ T cells after overnight stimulation of BAL and PBMCs with Sars-CoV-2 peptide pools shown as paired samples for the different peptide pools separately (left box) or all combined (right box). c,d, Number of viral antigens recognized ranked by response level in TNF- (c) or IFN-γ-producing (d) CD4⁺ and CD8⁺ T cells. e,f, Percentage of responders in BAL or PBMC samples for TNF⁺CD4⁺ or CD8⁺ T cells (e) and IFN-γ⁺CD4⁺ or CD8⁺ T cells (f). Responses were considered positive when above mean + 2 s.d. of DMSO control after overnight stimulation with SARS-CoV-2 peptide pools. g,h, Percentage of TNF (g) or IFN-γ (h) production by CD4⁺ or CD8⁺ T cells after overnight stimulation of PBMCs distributed according to positive detection of responses in BAL (n = 10 biologically independent samples examined over one independent experiment). Bars at median (a, b, g and h); Wilcoxon’s paired test (a and b); Mann–Whitney U-test (g and h).

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