Fig. 4: HCoV spike-specific T cell and antibody responses are higher in individuals with detectable Sars-CoV-2-reactive T cell responses in BAL. | Nature Immunology

Fig. 4: HCoV spike-specific T cell and antibody responses are higher in individuals with detectable Sars-CoV-2-reactive T cell responses in BAL.

From: Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2

Fig. 4: HCoV spike-specific T cell and antibody responses are higher in individuals with detectable Sars-CoV-2-reactive T cell responses in BAL.

a,b, Frequency of TNF- (a) or IFN-γ-producing (b) CD4+ and CD8+ T cells after overnight and 10-d stimulation of PBMCs with spike peptide pool from HCoVs 229E, NL63 and OC43 combined. c, Serum IgG to spike from HCoVs 229E, NL63, OC43 and HKU1 in arbitrary units (n = 10 (a and b) or n = 9 (c and d) biologically independent samples examined over one independent experiment). d, Serum IgG to Sars-CoV-2 spike and nucleoprotein in arbitrary units. a,b, Results are represented grouped as individuals who tested negative (BAL nonresponders) or positive (BAL responders) for Sars-CoV-2-specific T cells in BAL. Bars at median (a and b), floating bars indicating the mean, minimum and maximum values within the dataset (c and d); Mann–Whitney U-test (a and d).

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