Extended Data Fig. 8: Polyreactive CD4+ and CD8+ T cell responses in VNLR, VNHR and VR subjects. | Nature Immunology

Extended Data Fig. 8: Polyreactive CD4+ and CD8+ T cell responses in VNLR, VNHR and VR subjects.

From: Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination

Extended Data Fig. 8: Polyreactive CD4+ and CD8+ T cell responses in VNLR, VNHR and VR subjects.The alternative text for this image may have been generated using AI.

a-f, Flow cytometry analysis showing the percentage of CD25+CD69+ TCM1 (a, b) TEM1 (c, d) and TEM2 (e, f) cells on gated CD4+ (a, c, e) and CD8+ (b, d, f) T cells from VNLRs (n = 25), VNHRs (n = 24), and VR subjects (n = 12) at T0 and month 6, after 24h incubation with α-CD3 plus -CD28 beads and IL-2. The dotted black lines indicate the LOD. The dotted green lines indicate the LOS. The same subjects were longitudinally analyzed. Data are represented with background subtraction from paired unstimulated controls. Box plots indicate median, interquartile range, and minimum/maximum. Each dot of box plots represents the average between three technical replicates of the same subject. All data are pooled from multiple experiments. Statistics were calculated using two-sided Wilcoxon rank-sum tests.

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