Extended Data Fig. 4: IL-17D inhibits DDX5 to drive skin inflammation.
a, Immunoblot of Ddx5 in lesional skin from IMQ-treated wild-type mice (n = 2) at day 0 to day 5. b, Immunoblot of Ddx5 and IL-17D in lesional skin from IMQ-treated wild-type (n = 3) and Il17d–/– mice (n = 3). c, Immunofluorescence analysis of Ddx5+ cells in lesional skin from IMQ-treated wild-type and Il17d–/– mice (n = 5). Scale bars, 25μm. The dotted lines indicate the edge between epidermis and dermis. d, Representative photos of ears from MC903- or IMQ-treated wild-type (n = 5) and Il17d–/– mice (n = 5). e, Flow cytometry of CD45+ cells in lesional skin from IMQ-treated wild-type (n = 5) and Il17d–/– mice (n = 5). Data represent two independent experiments. **P < 0.01 and ***P < 0.001. P values were analyzed by unpaired, two-tailed Student’s t-test. Data are presented as mean ± s.e.m.
