Extended Data Fig. 5: Activation of CD93 inhibits DDX5 to drive skin inflammation.
a, Immunoblot of Ddx5 in lesional skin from IMQ-treated wild-type and Cd93–/– mice (n = 3). b, Representative photos of ears from MC903-treated (n = 7) or IMQ-treated (n = 4) wild-type and Cd93–/– mice. c, RT-qPCR of Cxcl1, Cxcl2, Ccl20, Il17a, Il23 and Il36γ in lesional skin from IMQ-treated wild-type (n = 5) and Cd93–/– mice (n = 4). d, RT-qPCR of DDX5 in NHEKs (n = 3) treated with 2.3 nM IL-17D after CD93 silencing. e, Immunoblot of p38, Akt, Smad2/3 and their phosphorylation in lesional skin from IMQ-treated wild-type (n = 5) and Cd93–/– mice (n = 5). Data represent two independent experiments. *P < 0.05, ** P < 0.01 and *** P < 0.001. P values were determined by unpaired, two-tailed Student’s t-test (e) or two-way ANOVA (d). Data are presented as mean ± s.e.m.
