An enduring antibody response is ultimately dependent on the generation and maintenance of long-lived plasma cells. New research describes the use of single-cell transcriptomics approaches to reveal the defining features of longevity in plasma cells.
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Acknowledgements
This work was supported by the National Health and Medical Research Council Australia (1155342 to S.L.N) and the Cancer Council Victoria Grant-in-Aid (to J.T. and S.L.N.)
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Tellier, J., Nutt, S.L. The secret to longevity, plasma cell style. Nat Immunol 23, 1507–1508 (2022). https://doi.org/10.1038/s41590-022-01340-w
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DOI: https://doi.org/10.1038/s41590-022-01340-w
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