Extended Data Fig. 4: scRNA-seq of CD45+ tumor-infiltrating immune cells. | Nature Immunology

Extended Data Fig. 4: scRNA-seq of CD45+ tumor-infiltrating immune cells.

From: YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells

Extended Data Fig. 4: scRNA-seq of CD45+ tumor-infiltrating immune cells.

a, A t-distributed stochastic neighbor embedding (t-SNE) plot from scRNA-seq showing 15 cell clusters of CD45+ tumor-infiltrating immune cells that were sorted from B16-OVA tumor-bearing Ythdf2f/f and Ythdf2cKO mice on day 14 post B16-OVA tumor inoculation. b, Immunoblotting showing expression of iNOS in anti-tumoral BMDMs and expression of Arg1 in pro-tumoral BMDMs from Ythdf2f/f and Ythdf2cKO mice. The numbers below a lane indicate expression of target proteins normalized to expression of β-actin. Data in b are representative of at least two independent experiments.

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