Extended Data Fig. 1: Recurrent CD4+ Tconv clones detected in the prostate of Treg cell-depleted mice are found at low frequencies amongst Tconv and Treg subsets of other reference datasets. | Nature Immunology

Extended Data Fig. 1: Recurrent CD4+ Tconv clones detected in the prostate of Treg cell-depleted mice are found at low frequencies amongst Tconv and Treg subsets of other reference datasets.

From: The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state

Extended Data Fig. 1: Recurrent CD4+ Tconv clones detected in the prostate of Treg cell-depleted mice are found at low frequencies amongst Tconv and Treg subsets of other reference datasets.The alternative text for this image may have been generated using AI.

Heat map displaying the 20 TCRα sequences from Fig. 1C and their corresponding log10 frequency in six groups of samples, as indicated. From left to right, these groups are Tconv cells from the prostate of Treg-depleted Foxp3DTR-EGFP males (n = 5), Tconv cells from the salivary glands of Treg-depleted Foxp3DTR-EGFP males (n = 5), Tconv cells from the prostate of untreated Aire−/− males (n = 9), Tconv cells from the prostate of untreated TRAMP males (n = 5), Tconv cells from the pooled secondary lymphoid organs (SLOs) of untreated wild-type Foxp3GFP males (n = 4), and Treg cells from the SLOs of untreated wild-type Foxp3GFP males (n = 4). Data from the latter two groups and Aire−/− group are taken from ref. 21. Each column represents one biological sample. ND = not detected.

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