Extended Data Fig. 10: Chemokine antibodies in Lyme disease (Borrelia infection) and clustering of COVID-19, HIV-1 and autoimmune diseases based on chemokine antibodies.
From: Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course
(a) AUC of ELISA showing chemokine antibodies in healthy controls (Control, n = 30) and in Lyme (Erythema migrans) during acute disease (n = 26) and at month 6 post-infection (n = 23). Average of two independent experiments. Horizontal bars indicate median values. Statistical significance was determined using Kruskal-Wallis test followed by Dunn’s multiple comparison test. (b) Heatmap representing the unsupervised hierarchical clustering analysis of COVID-19 convalescents (n = 71; Lugano cohort at month 6), HIV-1 (n = 24), AS (n = 13), RA (n = 13) and SjS (n = 13), based on normalized AUC of ELISA values for plasma IgG binding to 42 peptides comprising the N-loop of all 43 human chemokines. The distribution of the groups within each cluster is shown.
