Extended Data Fig. 8: Exacerbated DSS- induced colitis in intestinal epithelial Nlrp10-deficient mice. | Nature Immunology

Extended Data Fig. 8: Exacerbated DSS- induced colitis in intestinal epithelial Nlrp10-deficient mice.

From: Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation

Extended Data Fig. 8: Exacerbated DSS- induced colitis in intestinal epithelial Nlrp10-deficient mice.The alternative text for this image may have been generated using AI.

(a, b) Quantification of DSS colitis severity in Nlrp10loxP/loxPVil1+ and Nlrp10loxP/loxP littermate mice. (a) Representative colonoscopy images at day 7 after DSS initiation, (b) representative images of the colon length at day 12 after DSS initiation. (c–e) ELISA of (c) IL-6 (Mann-Whitney U test), (d) TNF-α (Mann-Whitney U test) and (e) IL-10 (Mann-Whitney U test) in supernatants of distal colon explants in Nlrp10loxP/loxPVil1+ vs. Nlrp10loxP/loxP littermate mice at day 12 after DSS initiation (Nlrp10loxP/loxP n = 8; Nlrp10loxP/loxPVil1+ n = 12) Mean ± SEM. *: p < 0.05. Statistical test used in (c-e) was two-sided.

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