The immune system is not immune to sex differences. New research now uncovers the molecular mechanisms that underlie sex-based differences during antiviral immune responses.
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References
Wilkinson, N. M., Chen, H. C., Lechner, M. G. & Su, M. A. Annu. Rev. Immunol. 40, 75–94 (2022).
Takahashi, T. & Iwasaki, A. Science 371, 347–348 (2021).
Jacobsen, H. & Klein, S. L. Front. Immunol. 12, 720952 (2021).
D’Agostino, P. et al. Ann. NY Acad. Sci. 876, 426–429 (1999).
Cheng, M. I. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01463-8 (2023).
Huang, Z. et al. Proc. Natl Acad. Sci. USA 118, e2023216118 (2021).
Berletch, J. B., Yang, F. & Disteche, C. M. Genome Biol. 11, 213 (2010).
Eckelhart, E. et al. Blood 117, 1565–1573 (2011).
Beyaz, S. et al. Nat. Immunol. 18, 184–195 (2017).
Hayakawa, Y. & Smyth, M. J. J. Immunol. 176, 1517–1524 (2006).
Menees, K. B. et al. Immun. Ageing. 18, 3 (2021).
Acknowledgements
A.G. is supported by the Hellenic Foundation for Research and Innovation (HFRI) under the 3rd Call for HFRI PhD Fellowships (fellowship no. 5691).
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Galaras, A., Verykokakis, M. UT(se)X differences during immune responses. Nat Immunol 24, 738–740 (2023). https://doi.org/10.1038/s41590-023-01481-6
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DOI: https://doi.org/10.1038/s41590-023-01481-6