Extended Data Fig. 7: Interactome analysis of tonsillar FRCs during homeostasis and inflammation. | Nature Immunology

Extended Data Fig. 7: Interactome analysis of tonsillar FRCs during homeostasis and inflammation.

From: PI16+ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches

Extended Data Fig. 7

a,b, Heatmaps depict outgoing and incoming number of interactions (a) and interaction strengths (b) of individual cell subsets. Colored bar plots represent the sum of column (incoming signal) or row (outgoing signal) values displayed in the heatmap. c, Relative contribution of each ligand-receptor pair to the overall communication network of COLLAGEN, FN1, TGFB and FGF signaling pathways. d, Heatmaps show relative importance of each cell subset based on network centrality measures for FGF and TGFB signaling pathway networks. e-i, Heatmaps show relative importance of each cell subset based on network centrality measures for CXCL, THBS, ICAM, IL6, and LIGHT signaling pathway networks. Circle plots in the right panel show inferred signaling networks of indicated ligand-receptor pairs. Edge width reflects the communication probability. Interactome analysis represents scRNA-seq data of 81,997 T and B cells from n = 2 adult patients with OSA and n = 3 adult patients with tonsillitis and 23,704 FRCs from n = 5 (Adult,OSA) and n = 4 (Adult,Tonsillitis) patients. Tcm, central memory T cells; Treg, regulatory T cells; Tfh, T follicular helper cells; CTL, cytotoxic T lymphocytes. GC, germinal center; MBC, memory B cells.

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