Fig. 2: Age-associated changes of the tonsillar stromal cell landscape. | Nature Immunology

Fig. 2: Age-associated changes of the tonsillar stromal cell landscape.

From: PI16+ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches

Fig. 2

a, Representative UMAPs of distinct tonsillar stromal cell types according to the PhenoGraph clustering algorithm based on forward scatter (FSC)-A, side scatter (SSC)-A, CD31, ACTA2, PDPN and UEA1 flow cytometry data of CD45−CD235a− cells (n = 3 pediatric and n = 3 adult patients with OSA). Epithelial cells (EpCs), ACTA2+ cells, BECs, LECs, FRCs and negative cells (N) are indicated. b, UMAPs show the expression pattern of the indicated markers. c–e, Quantification of the indicated stromal cell types as a percentage of CD45−CD235a− live cells in pediatric (n = 5) and adult (n = 6) patients with OSA. Data show average values of left and right tonsils for each patient. Mean and s.d. are indicated. P values were calculated with the two-sided Mann–Whitney test.

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