Extended Data Fig. 1: Epithelial cell topology in human palatine tonsils. | Nature Immunology

Extended Data Fig. 1: Epithelial cell topology in human palatine tonsils.

From: PI16+ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches

Extended Data Fig. 1

a-f, Representative immunofluorescence images of palatine tonsil sections from adult patients with OSA stained with the indicated antibodies and analyzed by confocal microscopy. a, Structure of the palatine tonsil. UEA1 staining of the lymphoreticular epithelium highlights deep crypts permeating palatine tonsils. b,d, High resolution analysis of the non-keratinized stratified squamous surface epithelium. PDPN-expressing basal cuboidal epithelial cells are highlighted (arrowheads). c,e, Morphology of the lymphoreticular crypt epithelium. Broadened PDPN-expressing basal layer of the crypt epithelium is highlighted (arrows). f, Lymphoreticular crypt epithelium occupied by CD11c+ myeloid cells. Boxed area shows magnified intraepithelial CD11c+ cells surrounding a blood vessel (asterisk). Microscopy images are representative for n = 3 adult patients with OSA.

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