Extended Data Fig. 2: Lymphoid tissue stromal cell topology in human palatine tonsils. | Nature Immunology

Extended Data Fig. 2: Lymphoid tissue stromal cell topology in human palatine tonsils.

From: PI16+ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches

Extended Data Fig. 2

a–h, Representative immunofluorescence images of palatine tonsil sections from adult patients with OSA stained with the indicated antibodies and analyzed by confocal microscopy. a,d, Epithelial and subepithelial areas (arrowheads) underpinned by PDPN+ stromal cells. Boxed area shows magnified epithelial-lymphoid tissue interface. b,e, B cell follicles with germinal centers (GC) and mantle zones (MZ) underpinned by PDPN+ FRCs. c,f, CD3+ lymphocytes in epithelial, germinal center (asterisk) and interfollicular T cell areas (arrowhead). g,h, T cell area surrounding B cell follicles (Fo) underpinned by PDPN+ FRCs (arrowhead) and ACTA2+ PDPN– VSMCs (arrow). Microscopy images are representative for n = 3 adult patients with OSA.

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