Extended Data Fig. 4: Statistical analyses of TCR gene segment usage in First Nations and non-Indigenous individuals. | Nature Immunology

Extended Data Fig. 4: Statistical analyses of TCR gene segment usage in First Nations and non-Indigenous individuals.

From: Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities

Extended Data Fig. 4: Statistical analyses of TCR gene segment usage in First Nations and non-Indigenous individuals.The alternative text for this image may have been generated using AI.

a, Scatter plot of frequency of TRAV segment in A2/S269-specific clonotypes by population. b, A subset of statistically significant motifs detected for the A2/S269 response. c, Cord plots depicting v-segment and j-segment pairings across TCR clonotypes for the A2/S269 response for NIA and FN populations. d, Smoothed frequency distributions of averaged nearest-neighbors TCRdist scores across NIA and FN populations for distinct epitopes. Left: alpha chains; middle: beta chains; right: paired alpha-beta chains. Numerical values in the legend correspond to the average neighbor distance for that repertoire. Lower values on the x-axis represent more similarity across TCR clonotypes. NIA, Non-Indigenous Adults; FN, First Nations Adults. ‘A’ indicates alpha chain, ‘B’ indicates beta chain. See Dash et al.59 for additional information on TCRdist and resulting characterizations.

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