Fig. 3: Chromatin accessibility analysis of FLS states reveals their distinct transcriptional regulation.
From: Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis
a, UMAP of 12 FLS clusters identified by tile-based scATAC-seq analysis after Harmony batch correction. b, Annotations of FLS states on the scATAC-seq UMAP. c, Projection of FLS states onto scATAC-seq UMAP. d, Heat map with top-six differentially accessible TF motifs identified by ChromVAR for each FLS state. Motifs filtered to include only those for which the corresponding TF was expressed by >20% of cells in the corresponding state. e, ChromVAR z scores projected onto scRNA-seq force-directed layout for a selection of top differentially accessible TF motifs derived from each FLS state.
