Extended Data Fig. 8: Influence of TCR usage on MAIT cell activation potential.
From: Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity
a,b, Spearman’s rank correlation between average TRBV pseudotimes on SCORPIUS and Slingshot (two trajectory analysis methods) TCR (a) and cytokine (b) trajectories. Pseudotime values scaled between 0 and 100. c,d, Spearman’s rank correlation between average TRBV pseudotimes for pairs of donors on SCORPIUS TCR (c) and cytokine (d) trajectories. e,f, Spearman’s rank correlation between average clonotype pseudotimes on SCORPIUS and Slingshot TCR (e) and cytokine (f) trajectories. Pseudotime values scaled between 0 and 100. Plots show stimulated cells only, TRBV gene segments with a frequency >1% in any donor (a-d) and clonotypes containing ≥20 cells (e, f).
