Extended Data Fig. 8: Strain-specific transcriptional regulation in response to LPS. | Nature Immunology

Extended Data Fig. 8: Strain-specific transcriptional regulation in response to LPS.

From: Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes

Extended Data Fig. 8: Strain-specific transcriptional regulation in response to LPS.The alternative text for this image may have been generated using AI.

a, Effect of LPS treatment on homeostatic strain-specific genes. Left panel shows differential expression of transcripts in LPS treated C57BL/6J and BALB/cJ Kupffer cells. Select genes that display differential expression under LPS treatment are shown in red, while genes that are non-specific are shown in black. Right panel shows parental strain-specific genes overlayed onto strain-specific expression under LPS treatment. b, Motif enrichment in strain-specific trans peaks following LPS treatment. c, De novo motif enrichment of C57BL/6J and BALB/cJ specific accessible enhancers following LPS treatment. d, De novo motif enrichment of C57BL/6J and BALB/cJ specific trans enhancers following LPS treatment. P values in c and d calculated under binomial distribution as implemented by HOMER.

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