Extended Data Fig. 6: Divided and undivided A2/M158+CD8+ TCRαβ repertoires across age groups. | Nature Immunology

Extended Data Fig. 6: Divided and undivided A2/M158+CD8+ TCRαβ repertoires across age groups.

From: Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan

Extended Data Fig. 6: Divided and undivided A2/M158+CD8+ TCRαβ repertoires across age groups.

TRAV and TRBV clonotype pairing for pooled donors within each age group, newborns (a), children (b), adults (c) and older adults (d), illustrated by circos plots for fast, slow, undivided and total A2/M158+CD8+ T cells. Left arch segment color indicates TRAV usage, right outer arch color depicts TRBV usage. Connecting lines indicate TRAV-TRBV gene pairing and are colored based on their TRAV usage and segmented based on their CRD3α and CDR3β sequence. The thickness is proportional to the number of TCR clones with the respective pair. The number of sequences considered for each circos plot is shown at the right bottom.

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