Extended Data Fig. 4: Gene expression profile induced by CARs upon antigen encounter. | Nature Immunology

Extended Data Fig. 4: Gene expression profile induced by CARs upon antigen encounter.

From: Harnessing CD3 diversity to optimize CAR T cells

Extended Data Fig. 4

a, b, Heatmaps of the pathway analysis, (a) Consensus and (b) Reactome. c, List of genes exclusively regulated by a single CAR construct compared to BB after 24 h stimulation with target cells. d, Pathway analysis (CAR T cells Nanostring) performed with the genes exclusively regulated by BBζ (up) or BBε (down) compared to BB upon 24 h stimulation with target cells. Two sample t-test, * indicates statistical significance, p < 0.05. Exact p values are provided in the source data file. n = 3 independent donors.

Source data

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