Extended Data Fig. 8: Impaired phosphorylation and nuclear translocation of STAT5 in IL-15-treated NOD1−/− and ΔCARD NOD1 naïve CD8+ T lymphocytes.
From: Microbial ligand-independent regulation of lymphopoiesis by NOD1
Naïve CD8+ T lymphocytes from WT, NOD1−/− and ΔCARD NOD1 mice were pretreated with or without rIL-15 (10 ng/ml) and cytosolic and nuclear fractions were probed with anti-STAT5 and anti-pSTAT5 Ab. Numbers indicate the intensity of STAT5 bands compared to tubulin or histone H3 protein controls for each cell compartment. Data shown from one representative out of two experiments performed.
