Extended Data Fig. 3: Impact of the loss of IL-1β, TNFα and OSM on MmSC inflammatory phenotypes. | Nature Immunology

Extended Data Fig. 3: Impact of the loss of IL-1β, TNFα and OSM on MmSC inflammatory phenotypes.

From: A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue

Extended Data Fig. 3

a, Population-level RNA-seq of MmSCs isolated from Il1b knock-out (KO) (n = 3) and wild-type (WT) (n = 2) littermates at D1 following CTX-induced injury. Volcano plot comparison of the different conditions. The 100-gene inflammatory signature is shown in red, with numbers at the top indicating up- and downregulated transcripts (in comparison with total transcript numbers in black). b, Same as (a) except B6 mice were treated with a combination of IL-1β, TNFα and OSM neutralizing antibodies or IgG isotype controls. P determined by Chi-squared test.

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