Extended Data Fig. 3: BCG induced prolonged serum cytokine and lung innate activation. | Nature Immunology

Extended Data Fig. 3: BCG induced prolonged serum cytokine and lung innate activation.

From: BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance

Extended Data Fig. 3: BCG induced prolonged serum cytokine and lung innate activation.

a, Extended data of kinetics of serum cytokine responses measured by Luminex. Data representative of two independent experiments; n = 10 (day 0), n = 4 (day 21), n = 5 (all other time points). b, Flow cytometry gating strategy of lung populations (Top) and cell frequencies (CD45+ live cells) of innate cells in lungs (Bottom). Data is representative of two independent experiments for day 21 and one representative experiment for other timepoints (n = 5-8). Data representative of two independent experiments at day 21 (n = 4) and one independent experiment for all other timepoints; n = 9 (day 0), n = 5 for all other timepoints. Statistical analysis was performed by One-way ANOVA with Tukey’s multiple comparisons test (a), One-way ANOVA with Dunnett’s multiple comparison test for each timepoint compared to day 0 (b). *, P < 0.05; **, P < 0.01; ***, P < 0.005; ****, P < 0.0001.

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