Extended Data Fig. 6: Baseline expression of ‘darkgreen module’ genes negatively associated with PPSV23 responses. | Nature Immunology

Extended Data Fig. 6: Baseline expression of ‘darkgreen module’ genes negatively associated with PPSV23 responses.

From: Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults

Extended Data Fig. 6: Baseline expression of ‘darkgreen module’ genes negatively associated with PPSV23 responses.The alternative text for this image may have been generated using AI.

a) Heatmap showing the modules correlated with PCV13 Rank, PPSV23 Rank, sex, age and Th1/Th17 ratio. b) Correlation between the expression of cytotoxic genes and age (in years) in an independent dataset. c) Correlation analysis between top correlates of darkgreen module (ANGEL2, and ZNF529) and PPSV23 Rank (n = 16). Correlation analysis between top correlates of darkgreen module (ANGEL2, and ZNF529) and PCV13 Rank (n = 14). d) Boxplot showing the expression of top correlates of darkgreen module (ANGEL2, and ZNF529) in men and women (n = 16). e) Association between ANGEL2, and ZNF529 expression with age (in years). Boxplots display the median and IQR (25–75%), with whiskers representing the upper- and lower-quartile ±1.5× IQR. The Wilcoxon Rank sum test (two-sided) was used to compare the expression of genes in men and women (e). Correlation analysis was performed using the Pearson correlation metric (b,c,e), and the p-value was computed using two-sided t test. The ‘n’ represents number of biological replicates.

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