Extended Data Fig. 10: Association between baseline CD16+ NK frequency estimated from CIBERSORTx and PCV13 vaccine responses. | Nature Immunology

Extended Data Fig. 10: Association between baseline CD16+ NK frequency estimated from CIBERSORTx and PCV13 vaccine responses.

From: Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults

Extended Data Fig. 10

a) Correlation between pre-vaccination cell frequency estimated by scRNA-seq and CIBERSORTx for different immune subtypes. b) Correlation analysis of CD16+ NK frequency at baseline and vaccine responsiveness Ranks of PCV13 (n = 14) and PPSV23 (n = 16), respectively. For the correlation analysis with PPSV23-Rank, cell frequency estimated by CIBERSORTx from the bulk PPSV23 baseline transcriptomes (n = 16) was considered. c) Correlation analysis of CD56bright NK frequency (n = 11) and Th1, and Th17 frequency at baseline. Pearson correlation was used to perform correlation analysis (a,b,c) and p-value was computed using two-tailed t-test. d) UMAP representation of CD16+ NK subsets in fluad responders (n = 3) and non-responders (n = 3) at baseline. Feature plots showing NCAM1, XCL1, FCG3RA and SPON2 in CD16+ NK cells in blue. Correlation analysis was performed using the Pearson correlation metric and p-value was computed using two-tailed t-test. The ‘n’ represents number of biological replicates.

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