Extended Data Fig. 9: H2-Db and 3BNC117-Db do not induce global T cell activation in hIL-15TgNSG mice.
From: Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
Frequency of peripheral blood CD4+ (left) and CD8+ (right) T cells that expressed HLA-DR and CD38 over time in the hIL-15TgNSG mice. Data shown for individual mice (top) and average percentages (bottom) (mean, SD). H2-Db (n = 9); 3BNC117-Db (n = 9). No significant differences between H2-Db- and 3BNC117-Db-treated mice at any time point or significant changes in frequencies of HLA-DR+CD38+ T cells compared to day 0 within either group at any time point were determined by two-way ANOVA followed by Šídák’s test for multiple comparisons.
