Fig. 3: PG16-Db and 3BNC117-Db promote NK cell-mediated elimination of HIV-1-infected cells.
From: Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
a, Representative flow plots showing the percentage of live GFP+CD4+ T cells after coculture with autologous NK cells alone or in the presence of 2,000 pM of H2-Db, PG16-Db, 3BNC117-Db, PG16-Ig or 3BNC117-Ig. b, Frequency of live GFP+CD4+ T cells (left) or p24 supernatant concentration (right) after coculture with autologous NK cells as in a relative to no scDb/IgG treatment. Data are reported as a percentage reduction (mean, s.d.) from three replicates. The significance was determined by two-way ANOVA followed by Dunnett’s test for multiple comparisons: *P < 0.05, ****P < 0.0001 comparing the scDb with the IgG conditions for both PG16 and 3BNC117 at the indicated concentrations.
