Extended Data Fig. 9: Analysis of HB-EGF in human pathology.
From: The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
a, immunostaining of a stereotactic biopsy from a patient with acute disseminated encephalomyelitis (ADEM; lower). DAPI staining (blue) of nuclei, CD3 staining (purple) of T cells, GFAP staining (red) of astrocytes, HB-EGF staining (green). Scale bar 100 μm. Patient characteristics are provided in Supplementary Table 4. b, ChromHMM features and genomic location of differentially methylated CpGs in the HBEGF locus in NeuN− glial cells from MS patients or non-neurological controls (NNCs). n = 8 MS, n = 14 NNCs. c, difference plot and area under the curve (AUC; d) of 0%, 25%, 50%, 75%, and 100% methylated genomic DNA used as a standard control.
