Extended Data Fig. 4: Serological analysis.
From: A method for predicting drugs that can boost the efficacy of immune checkpoint blockade
a, Serological analysis in B16-F10 tumor-bearing mice at 14 days after treatment indicated in Fig. 4e. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), blood urea nitrogen (BUN), and creatinine (CREA). Data are presented as means ± s.d. n = 7 (PBS), 4 (TRH), 5 (TSH), 7 (TH), 7 (Anti-PD-1), 7 (TRH+anti-PD-1), 8 (TSH+anti-PD-1) and 6 (TH+anti-PD-1). The red dashed line represents the range of normal reference values. b, c, TSH (b) and Thyroxine (T4) (c) content in the serum of B16-F10 tumor-bearing mice at 14 days after treatment indicated in Fig. 4e. Data are presented as means ± s.d. n = 6 (PBS), 4 (TRH), 5 (TSH), 6 (TH), 6 (anti-PD-1), 6 (TRH+anti-PD-1), 6 (TSH+anti-PD-1) and 5 (TH+anti-PD-1) for b; n = 6 (PBS), 4 (TRH), 5 (TSH), 6 (TH), 6 (Anti-PD-1), 6 (TRH+anti-PD-1), 6 (TSH+anti-PD-1) and 6 (TH+anti-PD-1) for c.
