Extended Data Fig. 4: Nearest neighbor clustering and cluster markers.

a, UMAP plot (as in Fig. 3b) with identified molecular clusters among the cells derived from Vwf-tdTomato⁻ Multi-HSC or Vwf-tdTomato⁺ P-HSC. Colors indicate individual clusters. b, Expression patterns of top genes defining clusters in a. c, UMAP reduction computed based on indicated numbers of variable genes generated independently of the analysis pipeline used to generate UMAPs shown in Fig. 3b. d, t distributed stochastic neighborhood embedding (t-SNE) of the cells in Fig. 3b.