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Host–pathogen interactions

Mycobacterial d-serine impairs TB control

Nature Immunology volume 25, pages 1129–1130 (2024)Cite this article

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Adaptation to hypoxia and immune escape are two hallmarks of Mycobacterium tuberculosis infection. The d-serine isomer has now been identified as a factor produced by M. tuberculosis upon hypoxic conditions, dampening CD8+ T cell responses.

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Fig. 1: d-serine secretion by Mycobacterium tuberculosis promotes immune escape.

References

  1. Cohen, S. B. et al. Cell Host Microbe 24, 439–446.e4 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Cohen, S. B., Gern, B. H. & Urdahl, K. B. Annu. Rev. Immunol. 40, 589–614 (2022).

    Article  CAS  PubMed  Google Scholar 

  3. Cheng, H. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-024-01701-1 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Galagan, J. E. et al. Nature 499, 178–183 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Mayer-Barber, K. D. & Barber, D. L. Cold Spring Harb. Perspect. Med. 5, a01842 (2015).

    Google Scholar 

  6. Woodworth, J. S. M. & Behar, S. M. Crit. Rev. Immunol. 26, 317–352 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Winchell, C. G. et al. J. Exp. Med. 220, e20230707 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Schurr, E. et al. Preprint at Research Square https://doi.org/10.21203/rs.3.rs-3889020/v1 (2024).

  9. Kramnik, I., Dietrich, W. F., Demant, P. & Bloom, B. R. Proc. Natl Acad. Sci. USA 97, 8560–8565 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ji, D. X. et al. Elife 10, e67290 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Sasabe, J. et al. Nat. Microbiol. 1, 16125 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France

    Maxime Caouaille, Denis Hudrisier & Olivier Neyrolles

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  1. Maxime Caouaille
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  2. Denis Hudrisier
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  3. Olivier Neyrolles
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Correspondence to Olivier Neyrolles.

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The authors declare no competing interests.

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Caouaille, M., Hudrisier, D. & Neyrolles, O. Mycobacterial d-serine impairs TB control. Nat Immunol 25, 1129–1130 (2024). https://doi.org/10.1038/s41590-024-01873-2

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